First Principles

Harvard Doctor: This Is What One Drink Actually Does to Your Brain

Published: September 24, 2026

Duration: 10:04

Think you know what one drink does to your brain? A Harvard addiction expert is about to change everything you thought about alcohol. Adrian Wells sits down with Dr. Sarah Wakeman to unpack the science behind why your brain literally rewires itself after that first sip, and why addiction isn't about willpower at all. 🎯 What You'll Learn: • Why there's actually no safe amount of alcohol (even moderate drinking increases cancer risk) • The 4 C's that define addiction medically: Control, Compulsion, Consequences, and Craving • How 40-60% of addiction risk comes down to genetics, just like diabetes or heart disease • Why addiction treatment got separat...