S4E3 - DNA-encoded library use in living cells for drug discovery

In this episode of Speaking of Mol Bio, host Steve Lewis speaks with Dr. Leif Larsen, Director of Biology at Vipergen, about the power of DNA-encoded libraries (DELs) in modern drug discovery. DEL technology enables researchers to screen extremely large chemical libraries by attaching a unique DNA barcode to each compound, allowing millions, or even hundreds of millions, of compounds to be analyzed simultaneously through sequencing. 

Larsen explains how Vipergen’s platform flips traditional screening methods by storing massive compound libraries in a single tube and identifying binding interactions through DNA sequencing. He also describes their proprietary Binder...