Probably Science

Comedian Shane Mauss (@shane_mauss) returns to the show to talk about his upcoming comedy special TRIPS: The First Dose, how LSD affects blind people, misophonia's link to anxiety and depression, the goring of a matador's ass, plants 'hearing' rain coming and Shane's comedy/science podcast Here We Are.

Comedian Brandie Posey (@brandazzle) returns to the show to talk with Jesse, Andy and Matt about the geography of Jersey, Brandie's label Burn This Records and her new comedy special Milk Job, Andy's other ska band, why humans can't regenerate limbs, a huge volcano refilling with magma, the dude who got both his arms reattached in 1992, whether Yellowstone is due for an eruption and Fruit Love Island.

Comedian/speechwriter Chandler Dean (@chandlerjdean) joins Jesse, Andy and Matt to talk about his show Abolish Everything!, Jesse's over-the-top stuffed animal purchase, poop speed as a health indicator, the Bristol Stool Chart, medical fake poo, Jesse's obsessions with fake foods, giant stuff and really tiny stuff, Artemis II's avatar crewmates, the magic of Tiny Empath Babies, videos of Tiny Empath Babies and more videos of Tiny Empath Babies.

Comedian Amber Preston (@prestonparty) returns to help Andy, Jesse and Matt celebrate the big six-oh-one and talk about Artemis II, frozen urine in space, a microbe that makes you stronger, Trump's insane handshakes, sharks testing positive for cocaine and sperm difficulties in zero-g.

Comedian Katie Novotny (@katienovotnyyyyy) joins Matt and Andy to discuss her special Son of Your Dreams, whale junk, headbutting whales, the 20-year cycle of fashion, an evolved arsenic tolerance, Thai children who can see underwater and a Warsaw Poland Bros. song Andy plays on.

Comedian Monica Nevi (@monicanevi) joins Andy, Jesse and Matt to talk about her special Big Stepdad Energy, what VO2 max means, esports scholarships, vasectomy rate spikes during March Madness, the effect of carbonated water on gamer performance, a bunch of human brain cells in a petri dish playing Doom, unlocking the antibacterial secrets of frogs and using frogs to keep milk from spoiling.

Comedian Matthew Coe (@matthew_coe__) joins Jesse, Andy and Matt to talk about parents watching comedy, Matthew's show My Therapist Knows Your Name, Matthew's hypoplastic right heart syndrome, the closing of the foramen ovale, a Japanese study of falling cats, a robot handling potato chips, and an averted Moon asteroid close call.

Comedian Jackie Kashian (@jackiekashian) returns to the show to talk with Jesse and Matt about her new standup special Alter-Kashian, huge amounts of hydrogen inside the Earth's core, weird things yawning does in your brain and a possible universal vaccine. See Matt on tour in Seattle and Portland, and Andy on tour in Santa Barbara.

Comedian and former marine biologist Forrest Shaw (@forrestshaw) returns to the show to talk with Matt, Andy and Jesse about his new live show The Ocean Hates You, his addiction podcast I've Got A Problem, bonnethead sharks, the rise of online sports gambling, a Kalshi market about aliens, and the myth of alpha wolves.

Comedian Aisha Alfa (@aishaalfa) joins Jesse, Andy and Matt to talk about comedy in Winnipeg, Jesse's Megyn Kelly-loved Olympics tweet, the cult movie Phantom of the Paradise, Andy's family friend Olympic ice dancer, the German word for a living stork with an arrow in it, the penis injection Olympic ski jumping controversy, an amazing artificial lung feat, Jesse's artificial lung cat bed, Aisha's newsletter and Andy's upcoming ska shows.

Comedian David Huntsberger returns to the show to talk with Matt, Jesse and Andy about his podcast Intercepts, his new platform The Endless Abyss, the lost art of sketch comedy albums, the world's worst redaction, Redactle, how dogs build their vocabularies like toddlers, Stella the talking dog, dumb dogs, breed stereotypes, Bad Will Hunting, the worst logo and name in education, longevity in meat-eaters and the foresight of The Machine Stops.

Comedian/neuroscientist Diya Basrai (@diyabasrai) joins Jesse, Andy and Matt to talk about Moravec's Paradox, whether there's something meat-specific about intelligence, a less-pessimistic AI take, a tool-using cow, Diya's comedy special and his comedy/science live show Uncontrolled Variables.

Comedian Jon Stringer (@jonjstringer) joins Andy, Jesse and Matt to talk about living in a converted rural Kansas church, the intricacies of comedy competitions and cruise ship comedy, dry ice PVC soupcan launchers, the oldest known use of poison arrows, retail blowguns and their misuse, vibe-coding a band manager, why you should stop using hydrogen peroxide on cuts, sword canes and pendulous doorknockers.

Comedian Imaan Hadchiti (@imaanfrankhadchiti) joins Jesse, Andy and Matt to talk about Rima syndrome, the movie Tiptoes, the passing of an art legend, sniffing farts to prevent Alzheimer's, what actually causes ice to be slippery, when physical aging really kicks in and making paralyzed rats walk again in a really creepy way.

Comedian/actor/writer/composer Waen Shepherd (@waenshep) joins Andy, Jesse and Matt to talk about the new album from his alter ego Gary Le Strange, the biology of elves, the best chocolate chip cookie recipe, a runaway supermassive black hole, a lemon-shaped exoplanet and the music of Gary Wilson.

Comedian/host/author Chris Duffy (@chrisiduffy) returns to the show to talk with Jesse, Andy and Matt about his new book Humor Me: How Laughing More Can Make You Present, Creative, Connected, and Happy, his radio show/podcast You're The Expert, his TED podcast How To Be a Better Human, the unintentionally phallic Covid-era Terry Crews video Chris worked on with Matt and Andy, prescribing standup to improve mental health, training Swedish crows to pick up cigarette butts and a frozen worm revived after 46,000 years.

Comedian Buddy Fitzpatrick (@buddycomic) joins Andy, Matt and Jesse to talk about Batman's effect on subway chivalry, the rooms of Madonna Inn, ladyfingers, manmade fire from 350,000 years earlier than previously thought, monogamy across the animal kingdom and an insane chain of rabies transmission via organ transplantation.

Comedian Adam Burke (@atpburke) joins Andy, Jesse and Matt to talk about Adam's new comedy special Unamerican, debunking the Stanford Prison Experiment, classic '80s Arnold movies, Matt and Jesse performing together in Nashville, the preacher who shot an escaped lab monkey, AIs that believe themselves to be more rational than humans, 3D printing with a mosquito proboscis, Andy's upcoming orchestra shows and Matt's upcoming San Deigo standup show.

Comedian/writer/NPR host Ophira Eisenberg (@ophirae) joins Andy, Jesse and Matt to talk about her podcast Parenting Is a Joke, her upcoming special produced by Lewis Black, the effect of venting on anger, a rage room show Andy worked on, why you should leave uncontacted tribes alone, the wombat-thief influencer and why you should speak up to seagulls.

Comedian Jess Zenisek (@jeffzenisek) joins Andy, Jesse and Matt to talk about tennis, homophobic sports stereotypes, Jesse's new ski persona, Mr. Wizard, Jeff's hair care regimen, a tiny tyrannosaur, a better rock-paper-scissors strategy, gray hair's relationship to cancer, the worst music to play during sex and the banger Parked By The Lake.